Butyrophenones

Not currently used at UAA. These compounds antagonize the neurotransmitters, dopamine and norepinephrine, in the CNS. Mimics the neurotransmitter, gamma-amino-butyric acid in the extrapyramidal system.

Legal: Alone these are not controlled substances. However, they are frequently used in combination with opioids which are controlled.

Indications: Azaperone may be used as a tranquilizer in some species. These drugs are also used in combination with opioids (particularly fentanyl) to produce neuroleptanalgesia. Relatively safe, short acting drugs. Minimal cardiovascular and respiratory effects (compared to other sedatives and tranquilizers).

Side effects: May reduce blood pressure.

Absorption, Fate, and Distribution: Can be administered IM, IV, and SC. Cleared through hepatic oxidation and glucuronic acid conjugation with renal excretion.

Contraindications:

Generic Name

Common Trade Names

Description

droperidol

Innovar-Vet

Only commercially available neuroleptanalgesic is Innovar-Vet (0.4mg fenatanyl + 20mg droperidol/ml). See definitions and also under opioids for further discussion of neuroleptanalgesia.

azaperone

Stresnil

Suicalm

Azaperone may be used alone as a tranquilizer or in combination with an opioid to provide neuroleptanalgesia. Has been used in combination with fentanyl for wildlife immobilization.